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. 2013 Nov 25;3:3325. doi: 10.1038/srep03325

Figure 5. Repeat administration study with naked RPN2-PnkRNA in vivo.

Figure 5

(a) Analysis of the efficiency of naked RPN2-PnkRNA upon the inhibition of lung tumor growth after inhaled (i.h.) administration once a week for 3 weeks with bioluminescent imaging. Representative images of scid mice on days 28, 35, 42 and 49. Each experimental regimen consisted of twelve animals. (b) The bioluminescent change (days 35, 42 and 49/pre-treatment day 28) emitted from the whole bodies of the mice on day 28 was set to 100%. Statistical analysis was performed by the Bonferroni multiple-comparison test. The data represent the means ± SD (n = 12). *, P < 0.05 versus naked control-PnkRNA group. (c) Haematoxylin eosin-stained sections of each of the right lower lobes from the same mice that were imaged in Figure 5a, treated with naked control-PnkRNA or naked RPN2-PnkRNA on day 49. The scale bars indicate 100 μm. (d) The ratio of tumor/normal tissue area (%) of HE staining (on day 49). The data represent the means ± SD (n = 12). Statistical analysis was performed using the Bonferroni multiple-comparison test. *, P < 0.05 versus naked control-PnkRNA group.