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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Clin Exp Allergy. 2013 Dec;43(12):10.1111/cea.12171. doi: 10.1111/cea.12171

TABLE 3.

Sensitivity, Specificity, PPV, and NPV of Enrollment SB-FENO, Bronchodilator Responsiveness, and the Asthma Predictive Index for Persistence of Wheezing and Acute Exacerbations of Wheezing

Persistence of Wheezing at Age 3 Years
Predictor Sensitivity Specificity PPV NPV
SB-FENO (>30ppb) 77 94 95 73
Tidal-FENO (>6.2ppb) 48 56 61 43
BDR 32 91 85 43
API 46 63 67 42
SB-eNO (>30ppb) +
positive API		 33 100 100 45
Acute Exacerbations of Wheezing between Ages 2.5 and 3 Years
Predictor Sensitivity Specificity PPV NPV
SB-FENO (>30ppb) 84 78 76 86
Tidal-FENO (>6.2ppb) 53 61 52 60
BDR 38 88 71 65
API 47 61 50 58
SB-eNO (>30ppb) +
positive API		 37 91 78 64

Definition of Abbreviations: PPV = positive predictive value; NPV = negative predictive value; SB-FENO = single-breath exhaled nitric oxide; Tidal-FENO = mixed expired exhaled nitric oxide during tidal breathing; BDR = bronchodilator responsive; API = Asthma Predictive Index (modified) defined as 1 of 2 major, or 2 minor criteria (major criteria = parental physician diagnosed asthma, or physician-diagnosed and treated eczema; minor criteria = physician diagnosed atopic dermatitis, or wheezing apart from colds).