Skip to main content
. Author manuscript; available in PMC: 2014 Oct 15.
Published in final edited form as: Eur J Pharmacol. 2013 Sep 11;718(0):10.1016/j.ejphar.2013.08.027. doi: 10.1016/j.ejphar.2013.08.027

Figure 3. PNU-120596 fails to enhance inhibition by bicuculline at positive membrane voltages.

Figure 3

Typical α7 nicotinic receptor-mediated responses of hippocampal CA1 striatum radiatum interneurons to brief (100 ms) puffs of 1 mM choline in the presence of 2 µM PNU-120596 and absence (A-B) or presence (C-D) of 25 µM bicuculline at negative (−60 mV; A and C) and positive (+60 mV; B and D) membrane potentials. PNU-120596 significantly enhanced inhibition by bicuculline at −60 mV, but not +60 mV. E) A summary of the effects obtained from five interneurons. The same set of neurons was tested in all experimental conditions.