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. Author manuscript; available in PMC: 2013 Nov 25.
Published in final edited form as: Endocr Relat Cancer. 2013 Sep 11;20(5):10.1530/ERC-13-0058. doi: 10.1530/ERC-13-0058

Figure 4.

Figure 4

Wnt/TCF target genes are induced in a mouse model of PPFP thyroid carcinoma. Thyroid RNA was prepared from 6 PPFP;PtenFF;Cre mice and 6 PtenFF;Cre control mice, and gene expression was analyzed by RT-qPCR. All of the genes analyzed are known to be induced by Wnt/TCF in other mammalian cell types, except for Nkx2-2 which is known to be repressed, and Pgk1 which is a neutral control gene used in addition to the normalization control gene Actb. For each gene, the average normalized expression in the PtenFF;Cre mice was set at 1. Each circle represents the data from one mouse, and the solid lines mark the average expression. For all genes the difference between PPFP;PtenFF;Cre and PtenFF;Cre is significant at P<0.001 except Nkx2-2 P=0.009, and Pgk1 P=0.57 (not significant).