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SR1664 does not inhibit thyroid tumor growth in vivo. Mice with thyroid-specific expression of PPFP and Pten deletion were treated with control diet, pioglitazone, or the selective PPARG agonist SR1664 for two weeks starting at age 8 weeks. Thyroid size was measured by ultrasound at the start and end of treatment. Each line represents one mouse. Thyroid area of wild type mice is 1.9 mm2 and does not change over the two week period (data not shown).
