Table 3.

Small molecules which elicited similar gene expression changes to the common PPFP profile, which were also Chembank HTS standard hits for Wnt inhibitor, Wnt/Lithium modulators, or β-catenin inducer/translocator.

name	mean score	n	enrichment	p	specificity	% non-null
verteporfin	−0.851	3	−0.969	0.00008	0.0058	100
colforsin	0.481	5	0.725	0.00364	0.0101	80
hymecromone	−0.479	4	−0.749	0.0079	0.0121	75
bisacodyl	−0.615	4	−0.748	0.00812	0.0403	75
simvastatin	0.6	4	0.742	0.00849	0.0247	100
amiloride	−0.603	5	−0.668	0.00953	0.0052	80
altizide	−0.315	4	−0.691	0.01971	0.0131	50
methotrexate	0.397	8	0.507	0.02008	0.1024	62
azacitidine	0.606	3	0.781	0.02119	0.1394	100
securinine	−0.584	4	−0.674	0.02524	0.1456	75
proadifen	−0.584	4	−0.671	0.02616	0.0261	75
merbromin	−0.345	5	−0.605	0.0272	0.1707	80
anisomycin	−0.498	4	−0.661	0.02988	0.1864	75
digoxin	−0.549	4	−0.659	0.03079	0.1122	75
lycorine	−0.379	5	−0.581	0.03827	0.28	60
fluspirilene	0.56	4	0.635	0.04372	0.1005	75

Mean score is the average connectivity score of control-treated pairs for a molecule in the CMAP database, n indicates the number such pairs. Enrichment indicates the relative connectivity of a particular set of instances compared against all other instances. Specificity indicates the relative uniqueness of connectivity by tallying the frequency at which the connectivity between the query and relevant instances is equaled or exceeded by the connectivity between the same instances and a large number of gene signatures from MSigDB. Non-null percentage refers to the number of instances that are scored in the same direction as the majority instances.