Reactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway

Volume 33, issue 3, e00046

In the published version of this paper, some errors were introduced by the publisher.

Equations 1 and 3 were incorrect. The correct equations are below.

Equation 1:

$$I_t=A-B{e}^{-k_{1,\mathrm{cd}}t}-C{e}^{-k_{2,\mathrm{cd}}t}$$

Equation 3:

$$I_t=A+B(1-e^{-k_{\mathrm{app},\mathrm{fl}}t})$$

Some values in Table 2 were incorrect. The correct version of Table 2 is below.

	kapp,fr (s−1)
Variant	50°C	n	55°C	n	60°C	n	Eact (kJ mol−1)
ATC232S	2.1±0.30×10−4	31	1.6±0.17×10−3	32	1.0±0.11×10−2	41	3.6±0.12×102
P14P12	0.58±0.074×10−4	18	0.43±0.18×10−3	17	0.24±0.020×10−2	18	3.3±0.32×102
P10P8	0.72±0.15×10−4	20	0.66±0.21×10−3	18	0.28±0.026×10−2	18	3.3±0.29×102
P6P4	0.098±0.075×10−4	15	0.44±0.10×10−3	29	0.55±0.12×10−2	21	5.5±0.53×102
P6	0.37±0.071×10−4	16	0.70±0.14×10−3	20	1.0±0.37×10−2	17	5.0±0.34×102
P4	1.1±0.47×10−4	13	1.1±0.28×10−3	32	0.78±0.27×10−2	17	3.8±0.47×102
P2P1′	2.2±0.79×10−4	13	1.7±0.15×10−3	22	1.2±0.21×10−2	18	3.6±0.26×102