Figure 1.

Putative mechanism underlying AT2R’s function in cardiovascular diseases. AT2R, Angiotensin II Type-2 Receptor; AT1R, Angiotensin II Type-1 Receptor; ARBs, Angiotensin Receptor Blockers; B2R, Bradykinin B2 Receptor; Gαi, G protein; NO, Nitric Oxide; cGMP, 3'-5'-cyclic guanosine monophosphate; NE, Norepinephrine; PP2A, Protein phosphatase 2A; MAPK, Mitogen-activated Protein Kinase; SHP-1, Src homology region 2 domaincontaining phosphatase; ERK1/2, Extracellular signal-regulated kinases 1 and 2