Table 3. Coefficients of determination obtained by Spearman rank test analysis of gene expression score as a predictor of plaque geometrical and compositional response variables based on intravascular ultrasound with radiofrequency backscatter analysis (IVUS/VH). Adjusting for multiple hypotheses (using a Bonferroni correction multiplier of 6) shows the P-values are at best weakly significant.
| IVUS/VH variable | Gene expression score |
|
|---|---|---|
| r2 | P-value | |
| Plaque volume | 0.55 | 0.018 |
| Non-calcified volume | 0.50 | 0.036 |
| Fibrous tissue volume | 0.34 | 0.16 |
| Fibro-fatty-tissue volume | 0.04 | 0.88 |
| Necrotic core volume | 0.56 | 0.015 |
| Dense calcium volume | 0.60 | 0.007 |