Table 1.
Genotype | Primary PSC | Metastasis | ||
---|---|---|---|---|
LN | Pleura | PER | ||
Arf+/+ | 0/10 (0) | 0/10 (0) | 0/10 (0) | 0/10 (0) |
Arf+/− | 0/10 (0) | 0/10 (0) | 0/10 (0) | 0/10 (0) |
Arf−/− | 5/10 (50) | 4/10 (40) | 5/10 (50) | 5/10 (50) |
Number of mice presenting with ≥ 1 indicated lesion (%). A subset of lung samples from urethane-exposed male mice of each genotype was selected at random for scoring. H&E stained sections were diagnosed blind to genotype. PSC, pulmonary sarcomatoid carcinoma; LN, lymph node; PER, peritoneal cavity.