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. Author manuscript; available in PMC: 2015 May 15.
Published in final edited form as: Oncogene. 2013 Jun 10;33(20):2665–2673. doi: 10.1038/onc.2013.208

Table 1.

Spectrum of disease in urethane-exposed mice1

Genotype Primary PSC Metastasis
LN Pleura PER
Arf+/+ 0/10 (0) 0/10 (0) 0/10 (0) 0/10 (0)
Arf+/− 0/10 (0) 0/10 (0) 0/10 (0) 0/10 (0)
Arf−/− 5/10 (50) 4/10 (40) 5/10 (50) 5/10 (50)
1

Number of mice presenting with ≥ 1 indicated lesion (%). A subset of lung samples from urethane-exposed male mice of each genotype was selected at random for scoring. H&E stained sections were diagnosed blind to genotype. PSC, pulmonary sarcomatoid carcinoma; LN, lymph node; PER, peritoneal cavity.

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