| Variable | Baseline | t=1 year | Difference (95% CI) between baseline andt= 1 year | P-value |
|---|---|---|---|---|
| Weight, kg | 79.5 (14.3) | 79.8 (14.9) | 0.3 (−0.4 to 1.1) | 0.340 |
| Waist circumference, cm | 101.3 (12.7) | 101.2 (12.9) | −0.1 (−1.1 to 0.9) | 0.790 |
| Creatinine, μmol/l | 109.0 (24.9) | 110.9 (25.4) | 1.8 (−2.0 to 5.6) | 0.340 |
| eGFR MDRD, ml/min/1.73m2 | 49.1 (7.9) | 48.6 (8.7) | −0.5 (−1.9 to 0.9) | 0.470 |
| Fasting glucose, mmol/l | 6.1 (1.5) | 6.4 (1.4) | 0.3 (0.07 to 0.53) | 0.010 |
| HbA1c, % | 6.3 (0.7) | 6.4 (0.8) | 0.07 (−0.01 to 0.14) | 0.080 |
| Total cholesterol, mmol/l | 4.9 (1.1) | 4.6 (1.1) | −0.3 (−0.5 to −0.1) | <0.001 |
| HDL cholesterol, mmol/l | 1.3 (0.4) | 1.4 (0.4) | 0.03 (−0.04 to 0.11) | 0.400 |
| Total cholesterol/HDL | 4.0 (1.2) | 3.6 (1.2) | −0.36 (−0.55 to −0.17) | <0.001 |
| LDL cholesterol, mmol/l | 2.9 (1.0) | 2.5 (0.9) | −0.35 (−0.52 to −0.19) | <0.001 |
| Triglycerides, mmol/l | 1.7 (0.8) | 1.7 (0.9) | −0.01 (−0.16 to 0.14) | 0.880 |
| Haemoglobin, mmol/l | 8.8 (1.0) | 8.7 (0.8) | −0.09 (−0.13 to 0.04) | 0.170 |
| MCV, fl | 91.8 (3.7)a | 91.7 (4.0)b | −0.01 (−0.7 to 0.7) | 0.970 |
| Serum albumin (g/L) | 43.3 (2.3)c | 43.3 (2.3) | 0.02 (−0.4 to 0.4) | 0.910 |
| Sodium, mmol/l | 140.1 (2.2) | 140.4 (2.1) | 0.33 (−0.12 to 0.79) | 0.150 |
| Potassium, mmol/l | 4.7 (0.6)d | 4.89 (0.54)d | 0.14 (0.02 to 0.26) | 0.020 |
| Calcium, mmol/l | 2.36 (0.09) | 2.28 (0.09) | −0.08 (−0.10 to −0.06) | <0.001 |
| Phosphate, mmol/l | 1.15 (0.15) | 1.04 (0.14) | −0.10 (−0.14 to −0.07) | <0.001 |
| Parathyroid hormone, pmol/l | 6.2 (3.5)e | 6.1 (2.6)e | −0.36 (−0.94 to 0.22) | 0.220 |
| Urine albumin/creatinine, mg/mmol | 3.0 (5.7)a | 3.9 (6.6)a | 0.78 (−0.20 to 1.76) | 0.120 |
| Body mass index, kg/m2 | 28.9 (4.6) | 28.9 (4.7) | −0.04 (−0.30 to 0.21) | 0.740 |
| Smoking status, number of patients smoking (%) | 13(14.4) | 11(12.2) | n/a | |
|
| ||||
| WONCA functional health status: | ||||
| Overall health | 2.9(0.9) | 3.0(0.8)c | 0.10 (−0.10 to 0.31) | 0.320 |
| Daily activities | 1.8 (1.1) | 2.1(1.2)c | 0.21 (−0.02 to 0.44) | 0.070 |
| Feelings | 1.8 (1.1) | 1.8(1.0)c | −0.01 (−0.24 to 0.21) | 0.910 |
| Physical fitness | 3.5 (0.9) | 3.4(1.0)c | −0.14 (−0.33 to 0.06) | 0.170 |
| Social activities | 1.5 (0.9) | 1.6(1.0)c | 0.01 (−0.20 to 0.22) | 0.910 |
| Change in health | 2.9 (0.6) | 2.8(0.6)c | −0.08 (−0.25 to 0.09) | 0.350 |
| Agents acting on the RAAS system (%) | 66 (73.3%) | 73 (81.1%) | 0.020 | |
| Lipid modifying agents (%) | 53 (58.9%) | 66(73.3%) | <0.001 | |
| Vitamin D (%) | 1(1.1%) | 14 (15.5%) | <0.001 | |
Values are given as mean and standard deviation or number (percentage).
a
One missing value.
b
Two missing values.
c
Three missing values. eGFR = estimated glomerular filtration rate. HbA1c = glycated haemoglobin. HDL = high-density lipoprotein. LDL = low-density lipoprotein. MCV = Mean Corpuscular Volume. MDRD = Modification of Diet in Renal Disease. RAAS = renin-angiotensin-aldosteron system. WONCA = World Organisation of National Colleges, Academies and Academic Associations of General Practitioners/Family Physicians.