Figure 1.
The metabolic interrelationships of glycolysis, the TCA cycle, the urea cycle, and glutaminolysis. Upward arrows in the boxes denote that the expression is increased in the ADIR cell lines or can be induced by ADI-PEG20; downward arrows in the boxes denote downregulation. Abbreviations are: ACC=acetyl CoA carboxylase, ADI=arginine deiminase, ASL=argininosuccinate lyase, ASS1=argininosuccinate synthetase 1, FAS=fatty acid synthase, Glu-6-P=glucose-6-phosphate; GDH=glutamine dehydrogenase, Glut1=glucose transporter 1, GLS1=kidney-type glutaminase, LDH-A=lactate dehydrogenase-A, NOS=nitroxide synthetase, OTC=ornithine carbamoyltransferase, PDH=pyruvate dehydrogenase, PHD=prolyl hydroxylation, TCA= tricaboxylic acid cycle,