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. Author manuscript; available in PMC: 2014 May 21.
Published in final edited form as: Nature. 2013 Oct 27;503(7476):410–413. doi: 10.1038/nature12642

Figure 3. Rev-erbα represses thermogenic programming.

Figure 3

a, BAT mRNA (n=6) and, b, protein from WT and Rev-erbα KO mice acutely exposed to cold for 6 h from ZT4-10. c, BAT mRNA following 3 h of NE administration from ZT7-10 (1 mg/kg i.p.) (n=3). d, Ucp1 mRNA levels in preadipocytes isolated from Rev-erbα KO mice and WT littermates in which either Rev-erbα or vector control has been ectopically expressed (n=4). e, Rev-erbα occupancy at the Ucp1 proximal promoter. Rev-erbα-specific peaks are shaded. g, Ucp1 gene expression in BAT over a 24 h period (n=3). * p<0.05, ** p<0.01, *** p <0.001 as determined by two-tailed Student’s t-test or one-way ANOVA with multiple comparisons and a Tukey post-test. Data are expressed as mean ± s.d.