Fig. 1.

CYP ω-hydroxylase overexpression or WIT003 promotes invasion in NSCLC cells. a H1299, SW-1573, and A549 cells were treated with various concentrations of WIT003 (0.01, 0.1, and 1 μmol/L each), and cell invasion was also measured in a 5-h transwell assay in a blinded manner. b Expression of CYP4A11 and CYP4F2 in A549 cells or 1 wk after transfection with CYP4A11. c Cell invasion was measured from A549 cells treated with WIT002, HET0016 or transfected with CYP4 A11 in a 5-h transwell assay. *P < 0.05, **P < 0.01 versus control group; Representative data are shown as mean ± SEM from a single experiment (n = 6)