Fig. 2.

CYP ω-hydroxylase in A549 cells promotes primary tumor growth, angiogenesis and metastasis to lungs in nude mice. Nude mice injected with A549 cells untransfected (control) or transfected CYP4 A11 (A549-CYP4A11). After 2 days, the mice were treated with or without HET0016 (10 mg/kg) or WIT002 (10 mg/kg). a Primary xenograft tumor volume growth curves. b Average primary tumor weight for each group after growth for 6 weeks. c Average microvessel density in primary tumors and around tumors were counted in a blinded manner (MVD; capillary vessel number per HPF). d Average number of lung metastases for each group in experimental metastasis model. e Representative photographs of the tumor sections examined by immunohistochemical staining for CD34 (×400 magnification). *P < 0.05, **P < 0.01 versus control group (n = 6)