Table 1.

FDA-approved indications for selected biological agents used in the treatment of rheumatoid arthritis^1,11,12

				Indications
Generic	Brand	Major mechanism	Mode of administration	Ankylosing spondylitis	Crohn disease	Ulcerative colitis	Plaque psoriasis	Psoriatic arthritis	Juvenile idiopathic arthritis	Rheumatoid arthritis	Renal transplant
Abatacept	Orencia	T-cell costimulation modulator	IV/ subcutaneous injection						X	X
Adalimumab	Humira	TNF- alpha inhibitor	Subcutaneous injection	X	X		X	X	X	X
Anakinra	Kineret	IL-1 receptor antagonist	Subcutaneous injection							X
Certolizumab pegol	Cimzia	TNF-alpha inhibitor	Subcutaneous injection		X					X
Etanercept	Enbrel	TNF-alpha inhibitor	Subcutaneous injection	X	Xa		X	X	X	X
Golimumab	Simponi	TNF-alpha inhibitor	Subcutaneous injection	X				X		X
Infliximab	Remicade	TNF-alpha inhibitor	IV injection	X	X	X	X	X	X	X
Tocilizumab	Actemra	IL-6 receptor antagonist	IV injection							X
Tofacitinib	Xeljanz	Jak1/2/3 inhibitor	Oral		Xb		Xb			X	Xb

Note: FDA = US Food and Drug Administration; IV = intravenous; TNF = tumor necrosis factor.

^aOff-label use.

^bInvestigational uses.