Table 2.

Pooled analysis of the phase 3 studies changes in irritable bowel syndrome Quality of Life Questionnaire scores⁵¹

Irritable Bowel Syndrome Quality of Life Scale	Linaclotide 266 mcg (n = 748)	Placebo (n = 742)	P
	Least squares mean change from baseline to week 12
Overall	17.5	13.1	< .001
Dysphoria	19.3	15.2	< .001
Interference with activity	12.8	11.3	.075
Body image	22.1	15.7	< .001
Health worry	25.2	17.9	< .001
Food avoidance	20.2	12.7	< .001
Social reaction	14.7	11.1	< .001
Sexual	14.7	10.4	< .001
Relationships	11.8	8.5	< .001