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Adverse reactions reported in ≥ 2% of linaclotide-treated (145 mcg) patients and at an incidence greater than in placebo group patients in the 2 phase 3, placebo-controlled trials (1 and 2) in irritable bowel syndrome with constipation1
| Adverse reactions | Linaclotide 145 mcg (n = 430) | Placebo (n = 423) |
| Diarrhea | 16% | 5% |
| Abdominal pain | 7% | 6% |
| Flatulence | 6% | 5% |
| Upper respiratory tract infection | 5% | 4% |
| Sinusitis | 3% | 2% |
| Abdominal distension | 3% | 2% |
