Figure 3.

Renal proximal tubule-specific survivin deletion delayed cell proliferation and increased apoptotic cells after I/R injury. (A) K_i-67 staining in survivin^ptKO or survivin^f/f mouse kidneys was performed at days 0, 2, 4, 7, and 14 after I/R injury. (B) The positively stained cells from A were counted in each field. Original magnification, ×400. (C) TUNEL staining in survivin^ptKO or survivin^f/f mouse kidneys was performed at day 2 after I/R injury. (D) The positively stained cells from C were counted in each field. Original magnification, ×200. Values are mean ± SEM (n=5–7 for each group). *P<0.05.