Figure 5.

All nephrotic syndrome complex groups have high UPodCR in association with higher level proteinuria. The FSGS progressor group (n=9) had on average a 92-fold higher median level of UPodCR compared with the normal median (P<0.001). Patients with a biopsy diagnosis of MCD or FSGS (who did not meet criteria for progression) had on average a 10- and 13-fold higher median UpodCR, respectively (P<0.001 compared with normal control), although the range varied up to >100-fold above normal, well within the FSGS progressor group range. The clinical descriptors SRNS, SDNS, and SSNS had similar median UPodCR values that were 16-, 14- and 16-fold above the control median, respectively. There were no significant differences in UPodCR values between FSGS, MCD, SDNS, SRNS, or SSNS groups with or without proteinuria. The patients with nephrotic syndrome complex as a whole who had been brought into remission by various treatments, resulting in reduction of proteinuria into the normal range (UProtCR ≤0.18), had significantly reduced UPodCR values toward the normal range (not significantly different from control). The box represents median and interquartile ranges, and error bars present 1.5-fold x the interquartile range below 25th and above 75th percentile. Means were compared using k-way ANOVA with post hoc Bonferroni correction for multiple comparisons. **P<0.001. NS, not significant.