Table 5.

Predictors of log plasma IL-6

Variable	Incident		Prevalent
	Coefficient	P Value	Coefficient	P Value
Age (per decade)	0.02a (0.007 to 0.04)	0.004	0.01 (−0.009 to 0.03)	0.3
Body mass index	0.0001 (−0.005 to 0.005)	0.96	0.004 (−0.002 to 0.01)	0.2
APD use	0.04 (−0.06 to 0.14)	0.4	0.003 (−0.08 to 0.09)	0.9
Systolic BP (per 10 mmHg)	0.003 (−0.007 to 0.014)	0.5	−0.009 (−0.02 to 0.004)	0.2
Male sex	0.05 (−0.001 to 0.09)	0.06	0.02 (−0.03 to 0.07)	0.5
Duration of PD (per yr)	−0.2 (−0.6 to 0.2)	0.4	0.02b (0.0008 to 0.03)	0.04
Biocompatible solution use	0.003 (−0.05 to 0.06)	0.9	−0.02 (−0.10 to 0.06)	0.6
Icodextrin use	0.04 (−0.02 to 0.11)	0.3	−0.02 (−0.09 to 0.05)	0.6
Average glucose concentration (per g/L)	0.003 (−0.004 to 0.009)	0.4	−0.002 (−0.01 to 0.005)	0.5
Dialysate IL-6	0.13a (0.07 to 0.18)	<0.001	0.09b (0.03 to 0.15)	0.002
Dialysate IFN-γ	0.07 (−0.003 to 0.15)	0.06	0.04 (−0.04 to 0.1)	0.3
Dialysate TNF-α	−0.2b (−0.3 to −0.005)	0.04	−0.1 (−0.4 to 0.06)	0.2
Plasma TNF-α	0.4a (0.2 to 0.5)	<0.001	0.4a (0.2 to 0.5)	<0.001
Plasma IFN-γ	0.05 (−0.03 to 0.13)	0.2	0.2a (0.07 to 0.3)	0.001
Plasma IL-1β	0.2b (0.001 to 0.4)	0.049	0.3b (0.07 to 0.5)	0.01
Diabetic	−0.05 (−0.1 to 0.007)	0.09	0.07b (0.002 to 0.15)	0.045
Comorbidity	0.05a (0.02 to 0.08)	0.001	0.02 (−0.01 to 0.05)	0.2
Urine volume (per L)	−0.02 (−0.05 to 0.01)	0.3	−0.009 (−0.05 to 0.03)	0.7
Korean	0.03 (−0.05 to 0.11)	0.4	−0.04 (−0.1 to 0.1)	0.4

A total of 497 and 310 patients were in the final models for incident and prevalent groups, respectively. Log₁₀ transformations of plasma IL-6 were used as the dependent variable. Cytokine coefficients are per log₁₀ changes in concentration. Using diabetes status rather than comorbidity was not a significant predictor in the incident group, but for the prevalent group diabetes was highly significant and there was a trend toward a better model with diabetes rather than comorbidity (Δ−2 log likelihood = 2.19). CI, confidence interval.

^aP<0.01.

^bP=0.01–0.05.