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. Author manuscript; available in PMC: 2014 Sep 11.
Published in final edited form as: J Am Chem Soc. 2013 Aug 26;135(36):10.1021/ja404714a. doi: 10.1021/ja404714a

Figure 2.

Figure 2

Multivalent peptide constructs used in preparing HDL-like peptide-lipid nanoparticles. (a) Schematic illustrations of the multivalent peptide constructs, which contain 2–4 copies of amphiphilic helical peptide ligated at the peptide N-terminus to small scaffolds via native chemical ligation. This study involves two series of constructs that differ in the length of the peptide subunit. (b) Helical-wheel diagrams for the peptide subunits used in this study, illustrating their amphiphilic nature. Color-coding in the helical wheels: yellow, hydrophobic; blue, cationic; red, anionic; green, polar uncharged.