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Methodologies to monitor mutagenesis and TLS. Chromosomal mutation assays (A) monitor, usually within a single target gene, a subset of mutagenic TLS events following the treatment of a cell culture with a mutagen. Several plasmid-based single adduct assays allow mutagenic (m_TLS) and error-free (ef_TLS) TLS events to be monitored quantitatively as well as qualitatively. The specific characteristics of the different assays (B–D) are outlined in the text.
