Figure 3.

Key intermediates of replication initiated by homologous recombination. The double-stranded DNA end is resected, exposing the single-stranded 3′ end. Strand invasion results in a D-loop intermediate. Bubble migration involves priming of leading- but not lagging-strand DNA synthesis (left), whereas full fork establishment involves coupling of leading- and lagging-strand synthesis (right). The solid line with arrowhead represents the invading 3′ end. Dashed lines represent new DNA synthesis.