Fig. 4.

Serial analysis for plasma methylation and CNA for cases TBR34 (A) and TBR36 (B). For methylation analysis, the innermost ring shows the MD of the buffy coat (black) and tumor tissues (purple). For CNA analysis, the innermost ring shows the CNA detected in the tumor tissues. For both types of analyses, from the second innermost ring outward, the plasma results for different time points are shown. (A) For TBR34, the plasma samples were taken before surgery, at 3 d and 2 mo after tumor resection, respectively. (B) For TBR36, the plasma samples were taken before surgery, at 3 d, 3 mo, 6 mo, and 12 mo after tumor resection, respectively.