Table 3.
Plasma hypomethylation and CNA analyses for multiple types of cancers
| Cancer type | Case no. | Staging*/tumor max dimension | Methylation analysis† | CNA analysis† | Classification based on the “OR” algorithm | Classification based on the “AND” algorithm |
| Percentage of bins with significant hypomethylation, % | Percentage of bins with copy no. gains or losses, % | |||||
| Breast cancer | TBR150 | Metastatic | 30.3 | 36.9 | Positive | Positive |
| TBR126 | T2N1M0 | 28.8 | 16.6 | Positive | Positive | |
| 4.5 cm | ||||||
| TBR127 | T2N1M0 | 6.8 | 0.4 | Positive | Negative | |
| 2.5 cm | ||||||
| TBR128 | T2N0M0 | 0.3 | 22.5 | Positive | Negative | |
| 2 cm | ||||||
| TBR111 | T1N0M0 | 0.3 | 1.7 | Positive | Negative | |
| 0.9 cm | ||||||
| Smooth muscle sarcoma | TBR051 | Metastatic | 7.5 | 59.4 | Positive | Positive |
| Neuroendocrine tumor | TBR052 | Metastatic | 100 | 80.3 | Positive | Positive |
| Lung cancer | TBR164 | Metastatic | 94.6 | 37.8 | Positive | Positive |
| TBR012 | Metastatic | 19.9 | 22.8 | Positive | Positive | |
| TBR014 | Metastatic | 5.9 | 6.8 | Positive | Positive | |
| TBR177 | T2N1M0 | 3.0 | 0.2 | Positive | Negative | |
| 3.9 cm | ||||||
| Nasopharyngeal cancer | TBR031 | Metastatic | 6.1 | 15.3 | Positive | Positive |
| TBR125 | Metastatic | 49.7 | 42.3 | Positive | Positive | |
| TBR124 | T4N1 | 0.0 | 0.5 | Negative | Negative | |
| TBR123 | T1N2M0 | 20.8 | 0.8 | Positive | Positive | |
| TBR062 | T3N1M0 | 0.0 | 0.3 | Negative | Negative | |
| TBR108 | T3N1M0 | 0.0 | 0.3 | Negative | Negative | |
| TBR107 | T3N0M0 | 1.9 | 2.6 | Positive | Positive | |
| TBR106 | T1N1M0 | 2.6 | 1.2 | Positive | Positive | |
| TBR099 | T1N0M0 | 16.2 | 0.4 | Positive | Negative |
*
According to Union for International Cancer Control/AJCC 2010 Cancer Staging Manual, 7th Ed. (31).
†
For methylation and CNA analyses, a positive result would be scored if the percentages of bins showing hypomethylation and CNA were >1.1% and 0.68%, respectively.