Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Characterization of the MenX–CRM197 conjugates tested in mice
| Conjugate | Conjugation chemistry | avDP MenX OS | MenX/CRM197, wt/wt | MenX/CRM197, mol/mol | Kd | Endotoxin, EU/µg |
| MenXOX–CRM197 | Random | 80 | 0.69 | 1.7 | 0.07 | 1.6 |
| MenX–ADH–SIDEA–CRM197 | Selective with longer spacer | 17 | 0.36 | 4.1 | 0.22 | 5.3 |
| MenX–NH2–SIDEA–CRM197 | Selective | 17 | 0.33 | 3.7 | 0.24 | 0.8 |
Kd values were of 0.33 for unconjugated CRM197 and of 0.24 and 0.40 for MenX OS of average degree of polymerization (avDP) 80 and 15, respectively.
