Fig. 4.

SEM examining the effect of functional connectivity in mediating between childhood experiences of maltreatment (measured by CTQ scores) and adolescent internalizing symptoms in girls (A) and boys (B). Connectivity variables included both total connectivity of the amygdala and hippocampus to sgACC and differential connectivity (the difference between the amygdala– and hippocampus–sgACC scores) to examine overall and relative effects of each region. (A) In girls, lower total functional connectivity of the amygdala and hippocampus to sgACC mediated the association between CTQ scores and internalizing symptoms. Lower amygdala–sgACC connectivity (i.e., a lower differential score) contributed more substantially to the association between CTQ scores and internalizing symptoms. (B) In boys, findings were similar except that lower hippocampus–sgACC connectivity (i.e., a higher differential score) contributed more substantially to this effect. The full model with moderation by sex is shown in Fig. 3.