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Impact of depleting NadE on Mtb during acute and chronic infections. (A) Growth and survival in mouse lungs (Left) and spleens (Right). Mice received doxy-containing food from day 1 (black), day 10 (orange), day 28 (purple), day 56 (green), or not at all (gray). Dotted lines end in data points for which the titer was below the limit of detection of 1 cfu/organ. Data are means ± SEM of three or four mice. (B) Gross pathology of lungs 168 d postinfection.
