Table 4.
The volume reduction and the center of mass displacements of target volumes in Con and Seq CRT (mean ± standard deviation)
| Target volume | CRT | Volume reduction (%) | Displacement (mm)
|
|||
|---|---|---|---|---|---|---|
| LR | CC | AP | 3D vector | |||
| GTV_T | Con | 42.6±19.8 (36.5, 48.8) | 1.1±2.4 (0.5, 1.6) | 0.1±1.2 (−0.2, 0.3) | −1.3±1.6 (−1.6, −0.9) | 4.0±2.7 (1.5, 6.5) |
| Seq | 35.1±20.6 (30.5, 39.8) | 1.0±4.2 (−0.4, 2.3) | −0.3±0.7 (−0.6, −0.1) | −1.3±1.4 (−1.8, −0.9) | 3.1±1.7 (2.1, 4.1) | |
| CTV_T | Con | 29.9±18.8 (24.1, 35.8) | 1.0±2.2 (0.5, 1.5) | 0.1±1.1 (−0.2, 0.3) | −1.4±1.4 (−1.7, −1.1) | 4.1±2.9 (1.4, 6.8) |
| Seq | 24.5±14.9 (21.1, 27.8) | 1.1±4.3 (−0.2, 2.5) | −0.2±0.9 (−0.4, 0.1) | −1.2±1.5 (−1.7, −0.8) | 3.0±1.5 (2.1, 3.9) | |
| GTV_Nl | Con | 61.7±22.0 (54.2, 69.1)* | −0.5±2.4 (−1.3, 0.4) | −0.2±4.6 (−1.7, 1.4) | −1.1±2.7 (−2.0, −0.2) | 5.3±2.9 (2.3, 8.3)* |
| Seq | 24.1±18.0 (12.7, 35.5) | −0.6±1.0 (−1.2, 0.1) | 0.5±0.8 (0.0, 1.0) | −0.1±0.6 (−0.5, 0.3) | 3.6±1.2 (2.8, 4.4) | |
| CTV_Nl | Con | 45.0±18.9 (38.6, 51.4)* | −0.2±2.4 (−1.0, 0.7) | 0.0±2.1 (−0.7, 0.7) | −0.3±1.3 (−0.8, 0.1) | 3.2±1.3 (2.0, 5.1) |
| Seq | 16.0±16.2 (5.7, 26.3) | −0.3±0.5 (−0.6, 0.1) | 0.3±1.3 (−0.5, 1.1) | −0.2±0.6 (−0.6, 0.2) | 3.7±1.4 (2.8, 4.6) | |
| GTV_Ns | Con | 53.2±27.5 (48.2, 58.1)* | 0.3±2.5 (−0.1, 0.8) | −0.5±2.6 (−1.0, 0.0) | −0.3±2.5 (−0.8, 0.2) | 4.1±1.7 (3.3, 4.8)* |
| Seq | 37.8±15.6 (31.2, 44.4) | −0.4±1.3 (−1.0, 0.1) | −0.3±1.2 (−0.8, 0.2) | 0.4±0.7 (0.1, 0.7) | 2.0±0.2 (1.7, 2.3) | |
| CTV_Ns | Con | 38.7±19.9 (35.1, 42.3)* | 0.3±2.4 (−0.2, 0.7) | −0.3±2.3 (−0.8, 0.1) | 0.1±2.3 (−0.3, 0.5) | 3.7±1.6 (2.9, 4.5) |
| Seq | 27.2±8.6 (23.6, 30.9) | −0.4±1.0 (−0.8, 0.1) | −2.5±2.8 (−3.7, −1.3)* | 0.6±1.5 (0.0, 1.2) | 3.5±2.7 (−0.9, 7.8) | |
| CTV_Lr | Con | 6.1±4.7 (5.0, 7.1)* | −0.2±1.7 (−0.5, 0.2) | 2.1±1.9 (1.7, 2.5) | 0.6±0.6 (0.4, 0.7) | 3.0±1.6 (2.1, 4.0)* |
| Seq | 3.1±2.5 (2.3, 3.9) | −0.2±0.8 (−0.4, 0.1) | 0.9±0.9 (0.6, 1.2)* | 0.5±0.5 (0.4, 0.7) | 1.6±0.4 (1.2, 2.0) | |
Note:
P-value,0.05, and the 95% confidence interval is shown in parentheses. A negative number means a shift to the right, caudal, and posterior in the LL, CC, and AP directions, respectively.
Abbreviations: Con, concurrent; Seq, sequential; CRT, chemoradiotherapy; LR, left–right; CC, cranial–caudal; AP, anterior–posterior; 3D, three-dimensional vector displacements; GTV_T, gross tumor volume of the primary tumor; CTV_T, clinical target volume of the primary tumor; GTV_Nl, gross tumor volume of the large lymph nodes (minimum diameter >3.0 cm); CTV_Nl, clinical target volume of the large lymph nodes; GTV_Ns, gross tumor volume of the small lymph nodes (minimum diameter >1.0 cm and ≤3.0 cm); CTV_Ns, clinical target volume of the small lymph nodes; CTV_Lr, clinical target volume of the elective region.