Table 2.

Clinical Findings in 14 Cases of Nonspecific Alphaviral Illness in Humans in Panama, 2010.

Patient No.	Location	Age	Sex	Date of Onset	Signs and Symptoms	Days after Onset	IgM ELISA	PRNT Titer*	RT-PCR	Viral Detection in Culture†	Cause
		yr				no.
247223	Metetί	35	Female	June 2	Fever, headache, arthralgia	8	Positive for EEEV, negative for VEEV	ND	ND	ND	EEEV
247320	Chepigana	38	Female	June 8	Fever, malaise	2	Negative for EEEV, positive for VEEV	EEEV <20, VEEV = 640	ND	ND	VEEV
247268	Pinogana	53	Male	June 11	Fever, headache	1	Negative for EEEV and VEEV	ND	ND	VEEV	VEEV
247852	Santa Rosa	39	Female	June 16	Fever, headache, malaise	15	Positive for EEEV, negative for VEEV	EEEV = 80, VEEV = 0	ND	Negative	EEEV
						35	Positive for EEEV, negative for VEEV	EEEV = 320, VEEV = 0
247696	Metetί	43	Male	June 17	Fever, headache, seizures, retro-orbital pain	6	Positive for EEEV, negative for VEEV	EEEV = 0, VEEV = 0‡	ND	ND	EEEV
247528	Yaviza	27	Female	June 17	Fever, headache	1	Negative for EEEV and VEEV	ND	Positive	VEEV	VEEV
247507	Metetί	19	Male	June 17	Fever, headache, vomiting	1	Negative for EEEV and VEEV	ND	Negative	VEEV	VEEV
247509	Rio Iglesia	41	Female	June 18	Fever	1	Negative for EEEV and VEEV	ND	Positive	VEEV	VEEV
247566	Rio Iglesia	4	Female	June 19	Fever, headache	1	Positive for EEEV and VEEV	EEEV = 40, VEEV = 0	Negative	ND	EEEV
247768	Chepigana	73	Male	June 23	Fever, headache	1	Negative for EEEV, positive for VEEV	EEEV = 0, VEEV = 320	ND	ND	VEEV
247603	El Real de Santa Maria	8	Female	June 23	Fever, headache vomiting	1	Positive for EEEV, negative for VEEV	EEEV = 40, VEEV = 0	ND	ND	EEEV
247600	Santa Fe	80	Male	June 24	Fever, confusion, retro- orbital pain, abdominal pain, diarrhea	7	Negative for EEEV and VEEV	EEEV = 0, VEEV = 40	ND	ND	VEEV
247770	Chepigana	16	Male	June 28	Fever, confusion, malaise	1	Positive for EEEV, negative for VEEV	ND	Negative	ND	EEEV
248025	Lajas Blancas	NA	Male	July 19	Fever, headache, arthralgia	3	Negative for EEEV and VEEV	ND	Negative	VEEV	VEEV

^*The titer is the reciprocal of the end-point dilution yielding 80% plaque reduction.

^†Vero cell cultures were used to isolate the virus from serum.

^‡The discrepancy between the results on the IgM ELISA assay and the PRNT titer in this case may be due to the formation of non-neutralizing antibodies, as described by Aguilar et al.⁷