Exemplar ITC titrations for: a, 75 μM Ca2+
2: C-lobeCaM into 7.5 μM CaV1.2 IQ domain and 50 μM C-lobeCaM EF34. b, 75 μM Ca2+
2: C-lobeCaM into 7.5 μM CaV1.2 IQ domain and 50 μM N-lobeCaMEF12. c, 75 μM Ca2+
2: C-lobeCaBP1 into 7.5 μM CaV1.2 IQ domain and 50 μM C-lobeCaBP1EF34. d, 75 μM Ca2+
2: C-lobeCaM into 7.5 μM CaV1.2 IQ domain and 50 μM CaMEF1234. e, 75 μM Ca2+
2: C-lobeCaBP1 into 7.5 μM IQ domain and 50 μM CaBP1EF34. Icons depict ITC components. N-lobes and C-lobes are green and blue, respectively. CaM and CaBP1 are in pastel and dark shades, respectively. White spheres represent Ca2+. Black crosses indicate mutated EF-hands. CaV1.2 IQ domain is shown in red.