. Author manuscript; available in PMC: 2013 Dec 1.

Published in final edited form as: Nat Genet. 2013 Oct 27;45(12):10.1038/ng.2814. doi: 10.1038/ng.2814

Table 2. Histone 3.3 mutations in bone and cartilage tumours.

Prevalence of histone 3.3 mutations identified in eight different tumour types are shown. K36M and G34W mutations are mutually exclusive in chondroblastoma and giant cell tumour of bone (p<1×10⁻¹⁵). Amino acid changes are specified above the bars.

Tumour type	Number screened	Mutated	H3F3A					H3F3B
Tumour type	Number screened	Mutated	G34L	G34R	G34V	G34 W	K36M	G34R	K36M
Chondroblastoma	77	73 (95%)					5		68
Giant cell tumour of bone	53	49 (92%)	1			48
Clear cell chondrosarcoma	15	1 (7%)							1
Osteosarcoma	103	2 (2%)		1				1
Conventional chondrosarcoma	75	1 (1%)					1
Chondromyxoid fibroma	43	0
Chordoma	25	0
Chondroma	7	0