| J Heinz[7] |
2010 |
650 |
61 |
58 |
End-stage renal disease |
29.0 |
2.5 mg folic acid, 25 ug vitamin B12, and 10 mg vitamin B6; 0.1 mg folic acid, 2 ug vitamin B12, and 0.5 mg vitamin B6 |
2.1 |
5 |
| ASFAST Study Group[8] |
2006 |
315 |
56 |
68 |
Chronic renal failure |
27.0 |
15 mg folic acid; placebo |
3.6 |
4 |
| DIVINe Study Group[9] |
2010 |
238 |
60 |
75 |
Diabetic nephropathy |
15.6 |
2.5 mg folic acid, 25 mg vitamin B6, and 1 mg vitamin B12; placebo |
3.0 |
4 |
| WAFACS Study Group[10] |
2008 |
5442 |
63 |
0 |
Health professionals |
NG |
2.5 mg of folic acid, 50 mg of vitamin B6, and 1 mg of vitamin B12; placebo |
7.3 |
3 |
| Veterans Affairs Site Investigators[11] |
2007 |
2056 |
66 |
98 |
Chronic kidney Disease or end-stage renal disease |
22.4 |
40 mg of folic acid, 100 mg of vitamin B6, and 2 mg of vitaminB12; placebo |
3.2 |
4 |
| Visp Trial Investigators[12] |
2004 |
3680 |
66 |
63 |
Ischemic stroke |
12.3 |
25 mg of vitamin B6, 0.4 mg of vitamin B12, and 2.5 mg of folic acid; 200 μg of vitamin B6, 6 μg of vitamin B12, and 20 μg of folic acid |
2.0 |
5 |
| SU.FOL.OM3 Collaborative Group[13] |
2010 |
2501 |
61 |
79 |
myocardial infarction, unstable angina, or ischaemic stroke |
12.8 |
Foloc acid (560 μg), vitamin B-6 (3 mg), and vitamin B-12 (20 μg) |
4.7 |
5 |
| SEARCH Collaborative Group [14] |
2010 |
12064 |
64 |
83 |
Myocardial infarction survivors |
13.5 |
2 mg folic acid plus 1 mg vitamin B12 daily; placebo |
6.7 |
4 |
| Polyp Prevention Study Group[15] |
2007 |
1021 |
57 |
64 |
Colorectal adenomas and no previous invasive large intestine carcinoma |
9.8 |
1 mg/d of folic acid daily; placebo |
7.0 |
4 |
| NORVIT Trial Investigators[16] |
2006 |
3749 |
63 |
74 |
Acute myocardial infarction within seven days |
13.1 |
0.8 mg of folic acid, 0.4 mg of vitamin B12, and 40 mg of vitamin B6; 0.8 mg of folic acid and 0.4 mg of vitamin B12; 40 mg of vitamin B6; or placebo |
3.3 |
5 |
| FAVORIT Study Group[17] |
2011 |
4110 |
52 |
63 |
Kidney transplant recipients |
16.4 |
5.0 mg folic acid, 50 mg vitamin B6, and 1.0 mg vitamin B12; 1.4 mg vitamin B6 and 0.002 mg vitamin B12 |
4.0 |
4 |
| M Righetti[18] |
2006 |
114 |
64 |
55 |
Hemodialysis |
31.7 |
5 mg folic acid plus vitamin B1 250 mg, vitamin B6 250 mg, vitamin B12 500 ug; untreated |
2.4 |
2 |
| WENBIT Study Group[19] |
2008 |
3096 |
62 |
80 |
Undergoing coronary angiography |
NG |
Folic acid, 0.8 mg, plus vitamin B12, 0.4 mg, plus vitamin B6, 40 mg; folic acid plus vitamin B12; vitaminB6 alone; placebo |
3.1 |
4 |
| EM Wrone[20] |
2004 |
510 |
60 |
50 |
End-stage renal disease |
32.9 |
15 mg folic acid, 12.5 mg vitamin B6, 6ug vitamin B12; 5 mg folic acid, 12.5 mg vitamin B6, 6ug vitamin B12; 1 mg folic acid, 12.5 mg vitamin B6, 6ug vitamin B12 |
2.0 |
4 |
| VITATOPS Study Group [21] |
2012 |
8164 |
63 |
64 |
Recent transient ischaemic attack or stroke |
14.3 |
2 mg folic acid, 25 mg vitamin B6, and 0·5 mg vitamin B12; placebo |
3.4 |
5 |
| A Liem[22] |
2005 |
593 |
65 |
78 |
Stable coronary artery disease |
12.1 |
0.5 mg folic acid; usual care |
3.2 |
3 |
| The Linxian Nutrition Intervention Trial[23] |
1996 |
3318 |
54 |
44 |
Esophageal dysplasia |
NG |
0.8 mg folic acid, 6 mg vitamin B6, and 0.018 mg vitamin B12; placebo |
6.0 |
3 |
| (HOPE) 2 Investigators[24] |
2006 |
5522 |
69 |
72 |
Vascular disease or diabetes |
12.2 |
2.5 mg of folic acid, 50 mg of vitamin B6, and 1 mg of vitamin B12; placebo |
5.0 |
4 |
