Table 6. miRNA expression and survival in non-smoking female lung adenocarcinoma by EGFR mutation status.
| EGFR | miRNAs | group | Number | HR (95% CI) | HR a (95% CI) | Log-rank P |
|---|---|---|---|---|---|---|
| Wild | miR-19a | LE | 23 | 1.00 | 1.00 | 0.686 |
| HE | 25 | 0.74(0.16-3.30) | 0.73(0.16-3.34) | |||
| miR-19b | LE | 22 | 1.00 | 1.00 | 0.857 | |
| HE | 26 | 1.15(0.26-5.13) | 1.20(0.27-5.41) | |||
| miR-195 | LE | 22 | 1.00 | 1.00 | 0.261 | |
| HE | 26 | 0.40(0.08-2.09) | 0.41(0.08-2.19) | |||
| miR-122 | LE | 21 | 1.00 | 1.00 | 0.671 | |
| HE | 27 | 0.73(0.16-3.26) | 0.84(0.16-4.37) | |||
| miR-590-5p | LE | 23 | 1.00 | 1.00 | 0.673 | |
| HE | 25 | 0.73(0.16-3.25) | 0.68(0.15-3.11) | |||
| mutant | miR-19a | LE | 29 | 1.00 | 1.00 | 0.026 |
| HE | 28 | 0.30(0.10-0.92) | 0.28(0.09-0.88) | |||
| miR-19b | LE | 30 | 1.00 | 1.00 | 0.033 | |
| HE | 27 | 0.32(0.10-0.97) | 0.28(0.09-0.91) | |||
| miR-195 | LE | 31 | 1.00 | 1.00 | 0.034 | |
| HE | 26 | 0.28(0.08-0.99) | 0.27(0.08-0.96) | |||
| miR-122 | LE | 32 | 1.00 | 1.00 | 0.008 | |
| HE | 25 | 0.22(0.06-0.75) | 0.23(0.06-0.81) | |||
| miR-590-5p | LE | 29 | 1.00 | 1.00 | 0.021 | |
| HE | 28 | 0.31(0.11-0.89) | 0.28(0.09-0.85) |
LE: Low Expression; HE: High Expression. LE and HE were divided by median expression of specific miRNA.
a
adjusted for stage, age and treatment