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. 2013 Nov 25;8(11):e75340. doi: 10.1371/journal.pone.0075340

Figure 5. P2Y receptors activate the expression of genes related with cell death in dystrophic fibers.

Figure 5

Normal and dystrophic fibers were stimulated with P2Y1 or P2Y2 agonists for 1(P2Y1 agonist) and 10 µM UTP-γS (P2Y2 agonist) induced a decrease in mRNA levels of Bax (A) and Bim (B) in normal fibers and an increase in the same mRNA levels in dystrophic fibers. mRNA levels of PUMA did not change in any fiber type (C), whereas mRNA levels of Bcl2 were reduced in normal and dystrophic fibers with agonists for both, P2Y1 and P2Y2 (D) (n = 4–6 for each gene). Data were expressed as mean ± SE. *p<0.05,**p<0.01,***p<0.001,****p<0.0001.