Table 3. Association between polymorphisms in alcohol metabolism genes and colorectal cancer risk (men only).
| SNP | Controls | Cases | OR1 | 95% CI | p-value |
| N (%) | N (%) | ||||
| ADH1B rs1229984 | 927 (51.9) | 860 (48.1) | 0.0096 | ||
| G/G | 513 (55.3) | 457 (53.1) | 1.00 | ||
| G/A | 360 (38.8) | 324 (37.7) | 1.04 | (0.85–1.26) | |
| A/A | 54 (5.8) | 79 (9.2) | 1.77 | (1.22–2.58) | |
| Recessive (A/A) | 54 (5.8) | 79 (9.2) | 1.75 | (1.21–2.52) | 0.0025 |
| ALDH2 rs886205 | 916 (51.8) | 854 (48.2) | 0.61 | ||
| T/T | 658 (71.8) | 637 (74.6) | 1.00 | ||
| T/C | 228 (24.9) | 189 (22.1) | 0.91 | (0.73–1.15) | |
| C/C | 30 (3.3) | 28 (3.3) | 1.16 | (0.67–1.99) | |
| Dominant (T/C-C/C) | 258 (28.2) | 217 (25.4) | 0.94 | (0.76–1.17) | 0.57 |
1
OR adjusted for age, ethnicity, religion, energy intake and physical activity.