Table I.
Clinical characteristics and pulmonary function tests of all patients studied.
| A, Lung tissue samples | ||||
|---|---|---|---|---|
|
| ||||
| Characteristics | Controls | IPF | NSCLC | p-value |
| No. | 21 | 29 | 10 | |
| Agea | 63.41±4.12 | 67.8±3.93 | 59.38±6.81 | p1, p2, p3=NS |
| Gender (M/F) | 17/4 | 21/8 | 9/1 | |
| Non-smoker | 9 | 13 | 0 | |
| Smokers | 6 | 5 | 8 | |
| Ex-smokers | 6 | 11 | 2 | |
| FEV1a | 85.31±8.49 | 75.64±4.23 | 83.78±5.74 | p1, p2, p3=NS |
| FVCa | 93.22±7.50 | 74.85±3.30 | 92.19±8.25 | p1<0.05, p2, p3=NS |
| FEV1/FVCa | 73.33±4.29 | 82.14±1.85 | 71.89±4.91 | p1, p3<0.05, p2=NS |
| DLCOa | 74.43±11.37 | 50.73±4.30 | - | p1<0.05 |
|
| ||||
| B, BALF samples | ||||
|
| ||||
| Characteristics | Controls | IPF | NSCLC | p-value |
|
| ||||
| No. | 12 | 23 | 31 | |
| Agea | 61.75±3.51 | 69.17±1.23 | 66.62±1.74 | p1, p2, p3=NS |
| Gender (M/F) | 10/2 | 18/5 | 27/4 | |
| Non-smoker | 5 | 9 | 2 | |
| Smokers | 4 | 3 | 18 | |
| Ex-smokers | 3 | 11 | 11 | |
| FEV1a | 86.78±8.71 | 77.88±3.45 | 82.34±4.71 | p1, p2, p3=NS |
| FVCa | 91.88±6.90 | 71.68±4.52 | 91.13±8.92 | p1, p3<0.05, p2=NS |
| FEV1/FVCa | 75.41±5.19 | 85.31±1.79 | 72.14±5.23 | p1, p3<0.05, p2=NS |
| DLCOa | 72.28±9.71 | 52.69±4.13 | - | p1<0.05 |
Values are expressed as the means ± SEM (standard error of the mean).
a
t-test; p<0.05 was considered to indicate a statistically significant difference.
NS, not significant. p1, IPF vs. controls; p2, NSCLC vs. controls; p3, IPF vs. NSCLC. NSCLC, non-small cell lung cancer; IFP, idiopathic pulmonary fibrosis; BALF, bronchoalveolar lavage fluid; M, male; F, female; FEV1, forced expiratory volume in 1 sec; FVC, forced vital capacity; DLCO, diffusing capacity for carbon monoxide.