Table 3. Summary of disease associations derived from meta-analysis of case-control studies.

Disease Outcome	Studies	Polymorphism	Effect (ORG ; 95% CI)	PQ	I2	PH
All Gram - infections	13	TLR4 896 A>G	1.10 (0.90-1.38)	0.01	52%	0.32
	6	TLR4 1196 C>T	1.11 (0.66-1.87)	0.02	61%	0.59
Helicobacter pylori	2	TLR4 896 A>G	0.91 (0.61-1.36)	0.79	-	-
Meningococcal Disease	4	TLR4 896 A>G	1.10 (0.90-1.34)	0.43	0	0.93
All Gram + infections	3	TLR4 896 A>G	1.28 (0.43-3.81)	0.01	77%	-
	2	TLR4 1196 C>T	1.09(0.13-9.09)	0.002	-	-
All parasitic infections	8	TLR4 896 A>G	1.59 (1.05-2.42)	<0.001	72%	0.72
	7	TLR4 1196 C>T	1.50 (0.88-2.56)	0.01	64%	0.5
Chagas Disease	2	TLR4 896 A>G	1.06 (0.53-2.14)	0.82	-	-
	2	TLR4 1196 C>T	1.03 (0.49-2.18)	0.76	-	-
Malaria	3	TLR4 896 A>G	1.31 (1.04-1.66)	0.71	0	-
	2	TLR4 1196 C>T	1.30 (0.64-2.65)	0.11	-	-
Periodontitis(Aggressive)	5	TLR4 896 A>G	1.04 (0.53-2.04)	0.07	52%	0.16
	4	TLR4 1196 C>T	0.78 (0.42-1.65)	0.29	20%	0.92
Periodontitis (Chronic)	10	TLR4 896 A>G	0.94 (0.75-1.18)	0.68	0	0.74
	9	TLR4 1196 C>T	1.12 (0.83-1.52)	0.74	0	0.93
RSV	2	TLR4 896 A>G	1.02 (0.72-1.44)	0.61	-	-
Sepsis	3	TLR4 896 A>G	0.81 (0.41-1.56)	0.16	45%	-
Tuberculosis	5	TLR4 896 A>G	1.18(0.80-1.73)	0.03	63%	0.43
	3	TLR4 1196 C>T	1.07 (0.81-1.42)	0.47	0	-
UTI (Children)	3	TLR4 896 A>G	1.41 (0.70-2.84)	0.21	35%	-

P_Q= p value for Q homogeneity test; P_H= p value for Harbord’s small study effects test, -=not applicable