Table 4. Summary of identified metabolites related to lipid metabolism.
| Super pathway | Sub-pathway | Biochemical name | TIB 5.5h/8.5h ratio | p value | q value |
|---|---|---|---|---|---|
| Lipid | Medium-chain fatty acid | caproate (6:0) | 1.11 | 0.076 | 0.808 |
| heptanoate (7:0) | 1.07 | 0.221 | 0.808 | ||
| caprylate (8:0) | 1.06 | 0.358 | 0.817 | ||
| pelargonate (9:0) | 1.05 | 0.325 | 0.817 | ||
| caprate (10:0) | 1.04 | 0.421 | 0.822 | ||
| undecanoate (11:0) | 1.13 | 0.137 | 0.808 | ||
| 10-undecenoate (11:1n1) | 1.18 | 0.271 | 0.817 | ||
| laurate (12:0) | 1.07 | 0.239 | 0.808 | ||
| 5-dodecenoate (12:1n7) | 1.15 | 0.515 | 0.836 | ||
| Carnitine metabolism | Deoxycarnitine | 1.02 | 0.911 | 0.907 | |
| Carnitine | 0.99 | 0.584 | 0.855 | ||
| 3-dehydrocarnitine | 1.08 | 0.261 | 0.817 | ||
| Acetylcarnitine | 1.09 | 0.426 | 0.822 | ||
| hexanoylcarnitine | 1.22 | 0.624 | 0.855 | ||
| octanoylcarnitine | 1.38 | 0.301 | 0.817 | ||
| decanoylcarnitine | 1.38 | 0.376 | 0.817 | ||
| 2-decenoyl carnitine | 1.29 | 0.095 | 0.808 | ||
| cis-4-decenoyl carnitine | 1.17 | 0.499 | 0.836 | ||
| Laurylcarnitine | 1.36 | 0.155 | 0.808 | ||
| palmitoylcarnitine | 1.15 | 0.382 | 0.817 | ||
| stearoylcarnitine | 1.18 | 0.426 | 0.822 | ||
| Oleoylcarnitine | 1.24 | 0.197 | 0.808 | ||
| Bile acid metabolism | Cholate | 2.41 | 0.355 | 0.817 | |
| Glycocholate | 1.15 | 0.796 | 0.881 | ||
| Deoxycholate | 1.38 | 0.059 | 0.808 | ||
| glycodeoxycholate | 1.03 | 0.776 | 0.881 | ||
| glycochenodeoxycholate | 1.18 | 0.606 | 0.855 | ||
| glycolithocholate sulfate | 0.92 | 0.890 | 0.897 | ||
| taurolithocholate 3-sulfate | 0.90 | 0.996 | 0.913 | ||
| glycocholenate sulfate | 1.23 | 0.008 | 0.465 | ||
| Taurocholenate sulfate | 1.22 | 0.602 | 0.855 | ||
| glycoursodeoxycholate | 0.92 | 0.510 | 0.836 | ||
| Lysolipid | 1-palmitoylglycerophosphoethanolamine | 1.17 | 0.101 | 0.808 | |
| 2-palmitoylglycerophosphoethanolamine | 1.20 | 0.295 | 0.817 | ||
| 1-stearoylglycerophosphoethanolamine | 1.18 | 0.107 | 0.808 | ||
| 1-oleoylglycerophosphoethanolamine | 1.01 | 0.479 | 0.833 | ||
| 2-oleoylglycerophosphoethanolamine | 0.93 | 0.397 | 0.817 | ||
| 1-linoleoylglycerophosphoethanolamine | 1.21 | 0.709 | 0.878 | ||
| 2-linoleoylglycerophosphoethanolamine | 1.15 | 0.242 | 0.808 | ||
| 1-arachidonoylglycerophosphoethanolamine | 0.93 | 0.609 | 0.855 | ||
| 2-arachidonoylglycerophosphoethanolamine | 1.01 | 0.891 | 0.897 | ||
| 1-myristoylglycerophosphocholine | 1.25 | 0.390 | 0.817 | ||
| 2-myristoylglycerophosphocholine | 1.77 | 0.066 | 0.808 | ||
| 1-pentadecanoylglycerophosphocholine | 1.30 | 0.201 | 0.808 | ||
| 1-palmitoylglycerophosphocholine | 1.22 | 0.154 | 0.808 | ||
| 2-palmitoylglycerophosphocholine | 1.29 | 0.327 | 0.817 | ||
| 1-palmitoleoylglycerophosphocholine | 1.24 | 0.388 | 0.817 | ||
| 2-palmitoleoylglycerophosphocholine | 1.07 | 0.916 | 0.907 | ||
| 1-heptadecanoylglycerophosphocholine | 1.24 | 0.145 | 0.808 | ||
| 1-stearoylglycerophosphocholine | 1.22 | 0.237 | 0.808 | ||
| 2-stearoylglycerophosphocholine | 1.21 | 0.155 | 0.808 | ||
| 1-oleoylglycerophosphocholine | 1.18 | 0.209 | 0.808 | ||
| 2-oleoylglycerophosphocholine | 1.26 | 0.279 | 0.817 | ||
| 1-linoleoylglycerophosphocholine | 1.22 | 0.419 | 0.822 | ||
| 2-linoleoylglycerophosphocholine | 1.22 | 0.580 | 0.855 | ||
| 1-eicosadienoylglycerophosphocholine | 1.19 | 0.178 | 0.808 | ||
| 1-eicosatrienoylglycerophosphocholine | 1.30 | 0.734 | 0.881 | ||
| 1-arachidonoylglycerophosphocholine | 1.29 | 0.359 | 0.817 | ||
| 2-arachidonoylglycerophosphocholine | 1.16 | 0.789 | 0.881 | ||
| 1-docosapentaenoylglycerophosphocholine | 1.21 | 0.776 | 0.881 | ||
| 1-docosahexaenoylglycerophosphocholine | 1.24 | 0.456 | 0.824 | ||
| 1-palmitoylglycerophosphoinositol | 1.04 | 0.707 | 0.878 | ||
| 1-stearoylglycerophosphoinositol | 0.92 | 0.249 | 0.817 | ||
| 1-arachidonoylglycerophosphoinositol | 0.91 | 0.523 | 0.836 | ||
| 1-palmitoylplasmenylethanolamine | 0.98 | 0.357 | 0.817 | ||
| Sterol & Steroid | Lathosterol | 0.92 | 0.351 | 0.817 | |
| Cholesterol | 1.11 | 0.030 | 0.808 | ||
| 7-alpha-hydroxycholesterol | 1.12 | 0.770 | 0.881 | ||
| 7-beta-hydroxycholesterol | 1.13 | 0.580 | 0.855 | ||
| dehydroisoandrosterone sulfate (DHEA-S) | 1.10 | 0.267 | 0.817 | ||
| epiandrosterone sulfate | 1.00 | 0.793 | 0.881 | ||
| androsterone sulfate | 1.03 | 0.995 | 0.913 | ||
| Cortisol | 1.07 | 0.525 | 0.836 | ||
| Cortisone | 0.94 | 0.375 | 0.817 | ||
| beta-sitosterol | 0.73 | 0.030 | 0.808 | ||
| 7-alpha-hydroxy-3-oxo-4-cholestenoate (7-Hoca) | 1.15 | 0.030 | 0.808 | ||
| 4-androsten-3beta,17beta-diol disulfate 1 | 1.01 | 0.232 | 0.808 | ||
| 4-androsten-3beta,17beta-diol disulfate 2 | 1.01 | 0.718 | 0.881 | ||
| 5alpha-androstan-3beta,17beta-diol disulfate | 0.96 | 0.734 | 0.881 | ||
| 5alpha-pregnan-3beta,20alpha-diol disulfate | 1.08 | 0.852 | 0.897 | ||
| pregnen-diol disulfate | 1.10 | 0.481 | 0.833 | ||
| pregn steroid monosulfate | 1.06 | 0.983 | 0.913 | ||
| andro steroid monosulfate 1 | 0.98 | 0.503 | 0.836 | ||
| andro steroid monosulfate 2 | 1.02 | 0.762 | 0.881 | ||
| 21-hydroxypregnenolone disulfate | 1.08 | 0.379 | 0.817 | ||
| pregnenolone sulfate | 1.03 | 0.556 | 0.855 | ||
| pregnanediol-3-glucuronide | 1.05 | 0.884 | 0.897 |
Sleep-loss-related significant and trending elevations in plasma metabolites are highlighted respectively in red and orange, whereas significant and trending declines are highlighted respectively in green and light green.