Table 5. Summary of identified metabolites related to carbohydrate and energy metabolism.
| Super pathway | Sub-pathway | Biochemical name | TIB 5.5h/8.5h ratio | p value | q value |
|---|---|---|---|---|---|
| Carbohydrate | Fructose, mannose, galactose, starch & sucrose metabolism | fructose | 0.76 | 0.369 | 0.817 |
| mannitol | 0.73 | 0.352 | 0.817 | ||
| mannose | 0.80 | 0.039 | 0.808 | ||
| sorbitol | 0.90 | 0.338 | 0.817 | ||
| Glycolysis, gluconeogenesis & pyruvate metabolism | 1,5-anhydroglucitol (1,5-AG) | 0.96 | 0.451 | 0.824 | |
| glycerate | 0.96 | 0.350 | 0.817 | ||
| glucose | 0.89 | 0.086 | 0.808 | ||
| 1,6-anhydroglucose | 1.51 | 0.001 | 0.186 | ||
| pyruvate | 0.90 | 0.364 | 0.817 | ||
| lactate | 1.07 | 0.440 | 0.824 | ||
| Nucleotide sugars & pentose metabolism | arabitol | 0.93 | 0.449 | 0.824 | |
| ribitol | 1.02 | 0.817 | 0.895 | ||
| threitol | 0.91 | 0.387 | 0.817 | ||
| gluconate | 0.66 | 0.086 | 0.808 | ||
| ribose | 0.71 | 0.360 | 0.817 | ||
| ribulose | 0.88 | 0.573 | 0.855 | ||
| xylitol | 0.96 | 0.884 | 0.897 | ||
| arabinose | 1.01 | 0.804 | 0.887 | ||
| xylose | 0.80 | 0.244 | 0.808 | ||
| xylonate | 0.74 | 0.088 | 0.808 | ||
| xylulose | 0.84 | 0.488 | 0.833 | ||
| Energy | Krebs cycle | citrate | 1.07 | 0.525 | 0.836 |
| cis-aconitate | 1.11 | 0.205 | 0.808 | ||
| alpha-ketoglutarate | 0.83 | 0.625 | 0.855 | ||
| succinate | 1.19 | 0.257 | 0.817 | ||
| succinylcarnitine | 1.14 | 0.115 | 0.808 | ||
| fumarate | 1.17 | 0.240 | 0.808 | ||
| malate | 1.27 | 0.075 | 0.808 |
Sleep-loss-related significant and trending elevations in plasma metabolites are highlighted respectively in red and orange, whereas significant and trending declines are highlighted respectively in green and light green.