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. Author manuscript; available in PMC: 2014 Jul 19.
Published in final edited form as: ACS Chem Biol. 2013 May 1;8(7):1435–1441. doi: 10.1021/cb400177q

Table 2.

Inhibitory effect on SENP enzymatic activity using a bioluminescent peptide substrate

Structure Code† NCI ID‡ SENP1 IC50(μM) SENP2 IC50(μM) SENP7 IC50(μM)
graphic file with name nihms475158t11.jpg SPI-01 NSC5068 5.9 ± 1.4 2.9 ± 1.6 3.5 ± 1.5
graphic file with name nihms475158t12.jpg SPI-02 NSC 16224 2.1 ± 1.9 2.0 ± 2.0 2.7 ± 1.8
graphic file with name nihms475158t13.jpg SPI-03 NSC 8676 3.8 ± 1.5 2.4 ± 1.8 4.8 ± 1.4
graphic file with name nihms475158t14.jpg SPI-04 NSC 34933 2.4 ± 1.8 2.3 ± 1.8 3.4 ± 1.5
graphic file with name nihms475158t15.jpg SPI-05 NSC 5067 13.3 ± 1.3 8.5 ± 1.3 4.6 ± 1.5
graphic file with name nihms475158t16.jpg SPI-06 NSC 70551 3.9 ± 1.4 3.7 ± 1.4 4.7 ± 1.7
graphic file with name nihms475158t17.jpg SPI-07 NSC 58046 ≫60 ≫60 1.9 ± 2.2
graphic file with name nihms475158t18.jpg SPI-08 NSC 22940 22.2 ± 1.5 17.2 ± 1.5 2.8 ± 1.6
graphic file with name nihms475158t19.jpg SPI-09 NSC 42164 > 60 6.8 ± 1.3 1.9 ± 2.1
graphic file with name nihms475158t20.jpg SPI-10 NSC 45551 2.4 ± 1.8 2.5 ± 1.7 2.0 ± 2.0
†

Designation for our library of SUMO-protease inhibitors (SPI)

‡

Designated by the National Cancer Institute