The Histamine signaling/immune response pathway is associated with survival from OVCA and colon cancer. A, Histamine signaling/immune response pathway. Thermometers indicate the directional change (upward or downward) in expression of genes associated with extra-pelvic implant samples. Numbers 1–2 at base identify the originating dataset (1 = grouped analysis, unique to NOSE versus extra-pelvic implant; 2 = individual analysis, common to ≥15 paired samples). B and C, Kaplan-Meier curves depicting the association between the chemokines/cell adhesion pathway PCA score (using median PCA threshold) and overall survival from OVCA (MCC dataset, n=142) and colon cancer (GSE17538, n=177), respectively. Log-rank test P values indicate significance.