CoQ10 does not antagonize in vitro growth inhibition effect of doxorubicin on breast cancer cell lines. MDA-MB-468 (A, C) and BT549 (B, D) cell lines were treated with CoQ10 for 24 hours before treatment with doxorubicin at IC50 value (40nM for MDA-MB-468 and 200nM for BT549) for 48 hours. Proliferation assay was used to determine growth inhibition effects of CoQ10 alone and in combination with doxorubicin (A, B). Additionally, colony formation assays were performed (C, D). Error bars represent one standard deviation. * Indicates P < 0.05.
Abbreviations: CoQ10, Coenzyme Q10; dox, doxorubicin