Fig. 3.

Postsynaptic effects of α₁-adrenoceptor agonist on HN excitability in Mecp2^−/Y mice. A: records of membrane potential, input resistance and spike frequency in response to current injection from an Mecp2^−/Y HN in control (top) and during PE (40 μM) application (bottom). B: frequency-time (f–t) relationship for the same neuron for the highest current intensities. C: frequency-current (f–I) relationship for the same neuron. D–F: bar graphs showing the effects of PE on membrane potential (D), input resistance (E), and spike frequency (F) of HNs from Mecp2^−/Y mice. *P < 0.05; **P < 0.01; n, number of neurons examined.