Table 3.

Adipocyte number in WT and PAPP-A KO mice

	Cell Number (×105)
	Males		Females
Weeks on HFD	WT	KO	WT	KO
ING
0	100 ± 8	80 ± 7	85 ± 9	78 ± 9
10	121 ± 14	82 ± 13	77 ± 9	63 ± 9
20	109 ± 11	115 ± 18	76 ± 9	63 ± 10
SS
0	79 ± 10	69 ± 8	89 ± 6	80 ± 12
10	95 ± 11	76 ± 11	50 ± 6	58 ± 8
20	82 ± 7	72 ± 9	77 ± 12	51 ± 5
pGON
0	83 ± 15	48 ± 4*	96 ± 16	43 ± 9*
10	73 ± 11	95 ± 28	97 ± 18	58 ± 6
20	99 ± 9	119 ± 24	127 ± 10	105 ± 26
pREN
0	18 ± 1	14 ± 2	24 ± 3	13 ± 3*
10	29 ± 3	24 ± 3	21 ± 3	15 ± 2
20	33 ± 7	25 ± 4	26 ± 3	24 ± 5
Mes
0	134 ± 28	131 ± 15	127 ± 24	122 ± 18
10	79 ± 12	113 ± 11	85 ± 7	101 ± 14
20	68 ± 6	89 ± 8	79 ± 21	106 ± 16

Adipocyte nos., calculated as described in materials and methods, are presented as means ± SE of n = 8–12 mice. Mice at 7 wk of age were fed a HFD for 10 and 20 wk. Mice of the same age and fed a chow diet for 10 wk are referred to as 0 wk on HFD.

^*Significant difference between WT and PAPP-A KO, P < 0.05.