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Effect of C21 on calcium influx in INS-1E cells. A: colocalization of insulin and AT2R by immunofluorescence staining. B: calcium influx evoked by acute C21 treatment. C: insulin secretion induced by 1 h C21 treatment. *P < 0.05 compared with the baseline (0 min), n = 22 cells. #P < 0.05 compared with 1.7 mM glucose group; @P < 0.05 compared with 16.7 mM glucose group, n = 5/group.
