Fig. 1.

Reduction of pancreatic Igf2 expression along perinatal development and in PRLR^−/− mice. Igf2 gene expression was determined by qPCR in whole pancreases from PRLR^+/+ and PRLR^−/− mice at embryonic day €18.5, postnatal day (D)0.5, and D6.5 developmental stages (n = 6–23/group). Relative expression was calculated as a ratio (amoles of Igf2/pmoles of 18S). Data are represented as means ± SE. NS, not significant. Nonparametric statistical analyses were performed between the 2 genotypes *P <0.05.