Fig. 8.

Oxygen flux at the surface of mouse islets decreased after coating with silica but was stable over time in culture. Flux was measured perpendicular to the islet surface in nonencapsulated mouse islets on day 0 (control, n = 3), 4 h (n = 3) after encapsulation, and 1 day (n = 3), 2 days (n = 3), 7 days (n = 3), and 21 days (n = 4) after encapsulation and culture. KCN was added during recording to inhibit cellular respiration and confirm cellular source of the measured flux. Open bars, before KCN treatment; filled bars, after KCN treatment; error bars, SD. *Significant difference at P < 0.05.