Fig. 1.

A: temporal evolution of body weight in mice fed a standard diet (STD), a high-fat diet (HFD), or HFD-losartan. B: changes in kidney weight between mice fed a STD, a HFD, or HFD-losartan. C: temporal evolution of blood glucose in mice fed a STD, a HFD, or HFD-losartan. T0 corresponds to day 0; T1 corresponds to week 30, just before starting losartan or placebo treatment; T2 corresponds to week 32; T3 and T4 correspond to weeks 34 and 36, respectively. A: values are means ± SE; n = 6–8 in each group. Statistical analyses were performed by two-way ANOVA followed by Newman-Keuls: *P ≤ 0.05 HFD and HFD-losartan vs. mice on STD and +P ≤ 0.05 vs. T0. B: values are means ± SE; n = 6–8 in each group. Statistical analyses were performed by one-way ANOVA followed by Newman-Keuls: *P ≤ 0.05 vs. mice on STD and #P ≤ 0.05 vs. mice on HFD. C: values are means ± SE; n = 6–8 in each group. Statistical analyses were performed by two-way ANOVA followed by Newman-Keuls: *P ≤ 0.05 HFD or HFD + losartan vs. mice on STD and +P ≤ 0.05 vs. T0.